Genotoxic Effects of Hypericum heterophyllum Vent

نویسندگان

  • Afide Öcal
  • Halil Erhan Eroğlu
چکیده

Hypericum species, growing wild in Anatolia, widely used in traditional medicine in Turkey. In order to determine the genotoxic effect of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. The increasing extract concentrations of Hypericum heterophyllum induced micronucleus. The rise of micronucleus shows that Hypericum heterophyllum at high concentrations may become carcinogenic and genotoxic. The positive correlation was observed between micronucleus and age. Also, the positive correlation was observed between micronucleus rates of female and male. Further studies will be needed to determine the effects of the main bioactive components isolated from this species on micronucleus.

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تاریخ انتشار 2012